{"id":27,"date":"2026-07-04T15:20:07","date_gmt":"2026-07-04T06:20:07","guid":{"rendered":"https:\/\/doicl.net\/blog\/?p=27"},"modified":"2026-07-04T15:20:11","modified_gmt":"2026-07-04T06:20:11","slug":"post-27","status":"publish","type":"post","link":"https:\/\/doicl.net\/blog\/post-27\/","title":{"rendered":"\u30ea\u30a6\u30de\u30c1\u306e\u8840\u6db2\u691c\u67fb\u304c\u9670\u6027\u3067\u3082\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff1f\u8840\u6e05\u53cd\u5fdc\u9670\u6027\u30ea\u30a6\u30de\u30c1\u3068\u306f|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af(\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a\uff09"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">\u8840\u6e05\u53cd\u5fdc\u9670\u6027\u30ea\u30a6\u30de\u30c1\uff08seronegative RA\uff09\u3068\u306f<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u5916\u6765\u3092\u53d7\u8a3a\u3055\u308c\u308b\u65b9\u304c\u3088\u304f\u300c\u75c5\u9662\u3067\u8840\u6db2\u691c\u67fb\u3092\u3057\u3066\u30ea\u30a6\u30de\u30c1\u3067\u306f\u306a\u3044\u3068\u8a00\u3063\u3066\u3082\u3089\u3048\u307e\u3057\u305f\u3002\u3067\u3082\u305d\u306e\u5f8c\u3082\u95a2\u7bc0\u306e\u75db\u307f\u304c\u7d9a\u304f\u3093\u3067\u3059\u3002\u300d\u3068\u304a\u8a71\u3092\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u306e\uff13\u5206\u306e1\u306f\u8840\u6db2\u691c\u67fb\u3067\u306f\u8a3a\u65ad\u3067\u304d\u306a\u3044\u306e\u3067\u3001\u3057\u3063\u304b\u308a\u3082\u3046\u4e00\u5ea6\u8abf\u3079\u3088\u3046\u3068\u304a\u8a71\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u8a3a\u65ad\u3068\u306a\u308a\u6cbb\u7642\u3067\u3088\u304f\u306a\u3063\u3066\u3044\u304f\u4eba\u3082\u305f\u304f\u3055\u3093\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305b\u3063\u304b\u304f\u3067\u3059\u306e\u3067\u3001\u3053\u3046\u3044\u3063\u305f\u8840\u6db2\u691c\u67fb\u3067\u8a3a\u65ad\u3067\u304d\u306a\u3044\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u3092\u307e\u3068\u3081\u305f\u6587\u732e\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review. 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class=\"wp-block-list\">\n<li>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u7d0420\u301c30\uff05\u306f\u8840\u6db2\u691c\u67fb\uff08RF\u30fb\u6297CCP\u6297\u4f53\uff09\u304c\u9670\u6027\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u8840\u6db2\u691c\u67fb\u3060\u3051\u3067\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3092\u5426\u5b9a\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li>\u8840\u6e05\u53cd\u5fdc\u9670\u6027\u3067\u3082\u95a2\u7bc0\u7834\u58ca\u304c\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8a3a\u65ad\u306b\u306f\u8a3a\u5bdf\u30fb\u95a2\u7bc0\u30a8\u30b3\u30fc\u30fbMRI\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7dcf\u5408\u7684\u306a\u8a55\u4fa1\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u6700\u65b0\u7814\u7a76\u3067\u306f\u3001\u65b0\u3057\u3044\u8840\u6db2\u30de\u30fc\u30ab\u30fc\u3084\u6ed1\u819c\u89e3\u6790\u306b\u3088\u308b\u500b\u5225\u5316\u533b\u7642\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u8840\u6db2\u691c\u67fb\u304c\u9670\u6027\u3060\u304b\u3089\u5b89\u5fc3\u300d\u3068\u306f\u8a00\u3044\u5207\u308c\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6c17\u306b\u306a\u308b\u75c7\u72b6\u304c\u7d9a\u304f\u5834\u5408\u306f\u3001\u65e9\u3081\u306b\u30ea\u30a6\u30de\u30c1\u5c02\u9580\u533b\u3078\u76f8\u8ac7\u3059\u308b\u3053\u3068\u304c\u3001\u95a2\u7bc0\u3092\u5b88\u308b\u305f\u3081\u306e\u7b2c\u4e00\u6b69\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u3042\u308b\u65b9\u306f\u30ea\u30a6\u30de\u30c1\u79d1\u3078<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u691c\u67fb\u304c\u9670\u6027\u3067\u3082\u3001\u6b21\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u7d9a\u304f\u5834\u5408\u306f\u30ea\u30a6\u30de\u30c1\u79d1\u3078\u306e\u53d7\u8a3a\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u671d\u306e\u624b\u306e\u3053\u308f\u3070\u308a\u304c30\u5206\u4ee5\u4e0a\u7d9a\u304f<\/li>\n\n\n\n<li>\u6307\u3084\u624b\u9996\u304c\u816b\u308c\u3066\u3044\u308b<\/li>\n\n\n\n<li>\u8db3\u306e\u6307\u3084\u8db3\u9996\u306b\u3082\u75db\u307f\u3084\u816b\u308c\u304c\u3042\u308b<\/li>\n\n\n\n<li>\u5de6\u53f3\u5bfe\u79f0\u306b\u95a2\u7bc0\u304c\u75db\u3080<\/li>\n\n\n\n<li>\u6570\u9031\u9593\u4ee5\u4e0a\u75c7\u72b6\u304c\u6539\u5584\u3057\u306a\u3044<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u6db2\u691c\u67fb\u3060\u3051\u3067\u300c\u7570\u5e38\u306a\u3057\u300d\u3068\u5224\u65ad\u305b\u305a\u3001\u5c02\u9580\u533b\u306b\u3088\u308b\u8a3a\u5bdf\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u611f\u60f3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30a6\u30de\u30c1\u3092\u8a3a\u65ad\u3059\u308b\u969b\u306b\u3088\u304f\u4f7f\u308f\u308c\u308b\u30ea\u30a6\u30de\u30c1\u56e0\u5b50\uff08RF\uff09\u3001\u6297\u30b7\u30c8\u30eb\u30ea\u30f3\u304b\u30da\u30d7\u30c1\u30c9\u86cb\u767d\u6297\u4f53(\u6297CCP\u6297\u4f53\uff09\u304c\u3069\u3061\u3089\u3082\u9670\u6027\u306e\u60a3\u8005\u3055\u3093\u3092\u3001seronegative RA\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u306e\u6587\u732e\u3067\u306fseronegative RA\u306e\u65b9\u306f\u5168\u4f53\u306e2\uff5e3\u5272\u3068\u8a71\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u65e9\u671f\u306e\u60a3\u8005\u3055\u3093\u3067\u306f50%\u5f31\u304cseronegative\u3060\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002(Arthritis Res Ther. 2019 Jun 6;21(1):140.)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u307b\u304b\u306bCRP\u3068\u3044\u3046\u708e\u75c7\u306e\u5024\u3084\u3001MMP-3\u3068\u3044\u3046\u95a2\u7bc0\u5185\u306e\u708e\u75c7\u3067\u3042\u304c\u308b\u5024\u3082\u53c2\u8003\u306b\u3057\u307e\u3059\u304c\u3001\u60a3\u8005\u3055\u3093\u306e\u4e2d\u306b\u306f\u305d\u306e\u3044\u305a\u308c\u3082\u4e0a\u6607\u3057\u306a\u3044\u4eba\u3082\u898b\u304b\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">seronegative\u304b\u3064CRP\/MMP-3\u304c\u4e0a\u6607\u3057\u3066\u3044\u306a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u8840\u6db2\u691c\u67fb\u3067\u307e\u3063\u305f\u304f\u624b\u304c\u304b\u308a\u304c\u306a\u3044\u72b6\u6cc1\u3067\u8a3a\u65ad\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u305a\u3001\u5c02\u9580\u533b\u3067\u3082\u975e\u5e38\u306b\u82e6\u52b4\u3059\u308b\u30b1\u30fc\u30b9\u3082\u591a\u3044\u306e\u304c\u5b9f\u60c5\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3093\u306a\u65b9\u306b\u306f\u95a2\u7bc0\u306eX\u7dda\u64ae\u5f71\u3084\u3001\u95a2\u7bc0\u8d85\u97f3\u6ce2\u691c\u67fb\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u8a3a\u65ad\u3002\u3069\u3046\u3057\u3066\u3082\u8a3a\u65ad\u304c\u3064\u3051\u304d\u308c\u306a\u3044\u6642\u306f\u3001\u60a3\u8005\u3055\u3093\u3068\u76f8\u8ac7\u3057\u306a\u304c\u3089\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u3081\u3066\u3044\u304f\u3088\u3046\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305fRF\/CCP\u304c\u9670\u6027\u3060\u3051\u3069\u95a2\u7bc0\u75c7\u72b6\u304c\u7d9a\u304f\u60a3\u8005\u3055\u3093\u306e\u4e2d\u306b\u306f\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u30fb\u76ae\u819a\u7b4b\u708e\u306a\u3069\u3001\u5b9f\u306f\u307b\u304b\u306e\u81a0\u539f\u75c5\u3060\u3063\u305f\u3068\u3044\u3046\u65b9\u3082\u591a\u304f\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p 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