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class=\"wp-block-paragraph\">\u6b63\u5e38\u306a\u4e0a\u76ae\u7d30\u80de\u306f\u6d99\u3084\u553e\u6db2\u3092\u5206\u6ccc\u3059\u308b\u3060\u3051\u3067\u3059\u304c\u3001\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4\u3067\u306f\u30b9\u30c8\u30ec\u30b9\u3084\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306a\u3069\u3092\u304d\u3063\u304b\u3051\u306b\u6d3b\u6027\u5316\u3057\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3055\u307e\u3056\u307e\u306a\u7269\u8cea\u3092\u653e\u51fa\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001T\u7d30\u80de\u3084B\u7d30\u80de\u304c\u96c6\u307e\u308a\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u7d9a\u3044\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3053\u3068\u304b\u3089\u8fd1\u5e74\u3067\u306f\u3001\u553e\u6db2\u817a\u4e0a\u76ae\u7d30\u80de\u306f\u5358\u306a\u308b\u300c\u653b\u6483\u3055\u308c\u308b\u5074\u300d\u3067\u306f\u306a\u304f\u3001\u75c5\u6c17\u3092\u9032\u3081\u308b\u300c\u4e3b\u5f79\u300d\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u65b0\u898f\u6cbb\u7642\u85ac\u5019\u88dc\u306b\u95a2\u3057\u3066\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome. Nat Rev Rheumatol. 2024 Aug;20(8):473-491.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4\u306e\u75c5\u614b\u306e\u7406\u89e3\u306f\u3001\u3053\u306e10\u5e74\u3067\u5927\u304d\u304f\u9032\u6b69\u3057\u307e\u3057\u305f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u307e\u3067\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u306f\u3001\u300c\u514d\u75ab\u7d30\u80de\u304c\u6d99\u817a\u3084\u553e\u6db2\u817a\u3092\u653b\u6483\u3059\u308b\u75c5\u6c17\u300d\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u73fe\u5728\u3067\u306f\u3001\u6d99\u817a\u3084\u553e\u6db2\u817a\u306e\u4e0a\u76ae\u7d30\u80de\u305d\u306e\u3082\u306e\u304c\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3046 <strong>epithelial cell-centered disease\uff08\u4e0a\u76ae\u7d30\u80de\u4e2d\u5fc3\u75be\u60a3\uff09<\/strong> \u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u8907\u6570\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u75c5\u6c17\u3092\u652f\u3048\u3066\u3044\u307e\u3059<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u708e\u75c7\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u306e\u304c\u3001\u8907\u6570\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u3001\u75c5\u614b\u306e\u4e2d\u5fc3\u3068\u3057\u3066\u6700\u3082\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u306e\u306f<strong>Type I\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u3068BAFF<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d3b\u6027\u5316\u3057\u305f\u4e0a\u76ae\u7d30\u80de\u3084\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\uff08pDC\uff09\u304b\u3089\u7523\u751f\u3055\u308c\u308bType I IFN\u306f\u3001JAK\/STAT\u7d4c\u8def\u3092\u4ecb\u3057\u3066BAFF\u7523\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BAFF\u306fB\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u81ea\u5df1\u6297\u4f53\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u7dad\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001IL-6\u3001IL-17\u3001IL-21\u3001TNF-\u03b1\u3001CXCL13\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u3001\u7d30\u80de\u5185\u306eJAK\/STAT\u3001NF-\u03baB\u3001PI3K\/AKT\u3001BTK\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306a\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3082\u8907\u96d1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u73fe\u5728\u3067\u306f\u3001<strong>\u4e00\u3064\u306e\u5206\u5b50\u3060\u3051\u304c\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u591a\u6570\u306e\u514d\u75ab\u7d4c\u8def\u304c\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5f62\u6210\u3057\u3066\u75c5\u614b\u3092\u652f\u3048\u3066\u3044\u308b<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u614b\u5f62\u6210\u306f\u3001\u6982\u306d\u6b21\u306e\u3088\u3046\u306a\u6d41\u308c\u3067\u9032\u884c\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<pre class=\"wp-block-code\"><code>\u907a\u4f1d\u7d20\u56e0\u30fb\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\n\u3000\u3000\u3000\u3000\u2193\n\u553e\u6db2\u817a\u30fb\u6d99\u817a\u4e0a\u76ae\u7d30\u80de\n\u3000\u3000\u3000\u3000\u2193\nTLR7\/8\u30fbTLR9\n\u3000\u3000\u3000\u3000\u2193\n\u5f62\u8cea\u7d30\u80de\u69d8\u6a39\u72b6\u7d30\u80de\uff08pDC\uff09\n\u3000\u3000\u3000\u3000\u2193\nType I IFN\n\u3000\u3000\u3000\u3000\u2193\nJAK\/STAT\n\u3000\u3000\u3000\u3000\u2193\nBAFF\n\u3000\u3000\u3000\u3000\u2193\nB\u7d30\u80de\u6d3b\u6027\u5316\n\u3000\u3000\u3000\u3000\u2193\n\u81ea\u5df1\u6297\u4f53\u7523\u751f\n\u3000\u3000\u3000\u3000\u2193\nT\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\n\u3000\u3000\u3000\u3000\u2193\n\u6162\u6027\u708e\u75c7\u30fb\u81d3\u5668\u969c\u5bb3<\/code><\/pre>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u75c5\u614b\u306e\u89e3\u660e\u304b\u3089\u3001\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u307e\u3067\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3084\u514d\u75ab\u6291\u5236\u85ac\u306b\u3088\u3063\u3066\u708e\u75c7\u3092\u5e83\u304f\u6291\u3048\u308b\u6cbb\u7642\u304c\u4e2d\u5fc3\u3067\u3057\u305f\u304c\u3001\u75c5\u614b\u5f62\u6210\u306b\u95a2\u308f\u308b\u5206\u5b50\u304c\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u3067\u3001\u300c\u75c5\u614b\u306e\u3069\u3053\u3092\u906e\u65ad\u3059\u308c\u3070\u708e\u75c7\u3092\u6b62\u3081\u3089\u308c\u308b\u306e\u304b\u300d\u3068\u3044\u3046\u8003\u3048\u65b9\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Type I IFN\u7d4c\u8def\u3092\u6291\u3048\u308b<\/li>\n\n\n\n<li>BAFF\u306b\u3088\u308bB\u7d30\u80de\u6d3b\u6027\u5316\u3092\u6291\u3048\u308b<\/li>\n\n\n\n<li>B\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u9664\u53bb\u3059\u308b<\/li>\n\n\n\n<li>BTK\u3084PI3K\u306a\u3069B\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u3092\u963b\u5bb3\u3059\u308b<\/li>\n\n\n\n<li>CD40\u3084ICOS\u306a\u3069T\u7d30\u80de\u30fbB\u7d30\u80de\u306e\u5171\u523a\u6fc0\u3092\u963b\u5bb3\u3059\u308b<\/li>\n\n\n\n<li>FcRn\u3092\u963b\u5bb3\u3057\u3066\u81ea\u5df1\u6297\u4f53\uff08IgG\uff09\u3092\u6e1b\u5c11\u3055\u305b\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3001\u75c5\u614b\u306e\u3055\u307e\u3056\u307e\u306a\u6bb5\u968e\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u5264\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3000\u3000\u3000\u3000\u3000\u30002024\u5e74\u6642\u70b9\u3067\u306e\u5404\u7a2e\u65b0\u85ac\u306e\u958b\u767a\u72b6\u6cc1<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u75c5\u614b\u7d4c\u8def\uff08\u6cbb\u7642\u6226\u7565\uff09<\/th><th>\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8<\/th><th>\u4e3b\u306a\u85ac\u5264<\/th><th>\u4e3b\u306a\u7d50\u679c\uff082024\u5e74\u6642\u70b9\uff09<\/th><\/tr><\/thead><tbody><tr><td><strong>\u2160\u578bIFN\u7523\u751f\u306e\u6291\u5236<\/strong><\/td><td>TLR7\/8<\/td><td>MHV370<\/td><td>\u958b\u767a\u4e2d\u6b62<\/td><\/tr><tr><td><\/td><td>RNA\uff08TLR\u523a\u6fc0\uff09<\/td><td>RSLV-132<\/td><td>\u75b2\u52b4\u30fbQOL\u6539\u5584<\/td><\/tr><tr><td><strong>\u2160\u578bIFN\u30b7\u30b0\u30ca\u30eb\u306e\u6291\u5236<\/strong><\/td><td>IFNAR<\/td><td>Anifrolumab<\/td><td>Phase II\u8a66\u9a13\u9032\u884c\u4e2d<\/td><\/tr><tr><td><\/td><td>JAK1\/2<\/td><td>Filgotinib\u3001Baricitinib\u3001Tofacitinib<\/td><td>\u9ad8\u6d3b\u52d5\u6027\u60a3\u8005\u3067\u6539\u5584\u50be\u5411<\/td><\/tr><tr><td><\/td><td>TYK2<\/td><td>Deucravacitinib<\/td><td>\u8a66\u9a13\u9032\u884c\u4e2d<\/td><\/tr><tr><td><strong>B\u7d30\u80de\u6d3b\u6027\u5316\uff08BAFF\u7d4c\u8def\uff09\u306e\u6291\u5236<\/strong><\/td><td>BAFF<\/td><td>Belimumab<\/td><td>\u6539\u5584\u50be\u5411<\/td><\/tr><tr><td><\/td><td>BAFF-R<\/td><td>Ianalumab<\/td><td>ESSDAI\u6539\u5584\u3001ESSPRI\u306f\u6709\u610f\u5dee\u306a\u3057<\/td><\/tr><tr><td><\/td><td>BAFF\/APRIL<\/td><td>Telitacicept<\/td><td>ESSDAI\u6709\u610f\u6539\u5584<\/td><\/tr><tr><td><strong>B\u7d30\u80de\u9664\u53bb<\/strong><\/td><td>CD20<\/td><td>Rituximab<\/td><td>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u5dee\u306a\u3057<\/td><\/tr><tr><td><\/td><td>CD20\uff0bBAFF<\/td><td>Rituximab\uff0bBelimumab<\/td><td>\u6539\u5584\u50be\u5411<\/td><\/tr><tr><td><strong>B\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6291\u5236<\/strong><\/td><td>BTK<\/td><td>Tirabrutinib<\/td><td>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u5dee\u306a\u3057<\/td><\/tr><tr><td><\/td><td>PI3K\u03b4<\/td><td>Seletalisib<\/td><td>\u7d44\u7e54\u5b66\u7684\u6539\u5584\u3001\u81e8\u5e8a\u52b9\u679c\u306f\u9650\u5b9a\u7684<\/td><\/tr><tr><td><strong>T\u7d30\u80de\uff0dB\u7d30\u80de\u5171\u523a\u6fc0\u306e\u6291\u5236<\/strong><\/td><td>CD80\/86<\/td><td>Abatacept<\/td><td>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u5dee\u306a\u3057\uff0848\u9031\u3067\u306f\u6539\u5584\u50be\u5411\uff09<\/td><\/tr><tr><td><\/td><td>ICOSL<\/td><td>Prezalumab<\/td><td>\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u5dee\u306a\u3057<\/td><\/tr><tr><td><\/td><td>CD40<\/td><td>Iscalimab<\/td><td>\u9759\u6ce8\u7fa4\u3067ESSDAI\u6539\u5584<\/td><\/tr><tr><td><\/td><td>CD40L<\/td><td>Dazodalibep<\/td><td>ESSDAI\u30fbESSPRI\u3068\u3082\u6539\u5584<\/td><\/tr><tr><td><strong>\u81ea\u5df1\u6297\u4f53\uff08IgG\uff09\u306e\u6e1b\u5c11<\/strong><\/td><td>FcRn<\/td><td>Nipocalimab\u3001Efgartigimod<\/td><td>Phase II\u8a66\u9a13\u9032\u884c\u4e2d<\/td><\/tr><tr><td><strong>\u514d\u75ab\u30ea\u30bb\u30c3\u30c8<\/strong><\/td><td>CD19 CAR-T<\/td><td>CAR-T\u7d30\u80de\u7642\u6cd5<\/td><td>\u96e3\u6cbb\u4f8b\u3067\u671f\u5f85\u3055\u308c\u308b\u6cbb\u7642<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u306a\u305c\u671f\u5f85\u3055\u308c\u305f\u85ac\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u671f\u5f85\u3055\u308c\u305f\u85ac\u5264\u304c\u5fc5\u305a\u3057\u3082\u826f\u597d\u306a\u7d50\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001B\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3084\u3001T\u7d30\u80de\u3068B\u7d30\u80de\u306e\u5171\u523a\u6fc0\u3092\u963b\u5bb3\u3059\u308b\u30a2\u30d0\u30bf\u30bb\u30d7\u30c8\u306f\u3001\u7406\u8ad6\u4e0a\u306f\u6709\u671b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u9054\u6210\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001BAFF\/APRIL\u3092\u6a19\u7684\u3068\u3059\u308bTelitacicept\u3084\u3001CD40L\u3092\u6a19\u7684\u3068\u3059\u308bDazodalibep\u306a\u3069\u3067\u306f\u3001\u6709\u671b\u306a\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u9055\u3044\u306e\u80cc\u666f\u306b\u306f\u3001**\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4\u3068\u3044\u3046\u75c5\u6c17\u306e\u591a\u69d8\u6027\uff08heterogeneity\uff09**\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u306b\u306f\u3001\u3059\u3079\u3066\u306e\u60a3\u8005\u3055\u3093\u3067\u540c\u3058\u514d\u75ab\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Type I IFN\u304c\u5f37\u304f\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093<\/li>\n\n\n\n<li>BAFF\u7d4c\u8def\u304c\u4e3b\u4f53\u306e\u60a3\u8005\u3055\u3093<\/li>\n\n\n\n<li>B\u7d30\u80de\u6d3b\u6027\u5316\u304c\u4e2d\u5fc3\u306e\u60a3\u8005\u3055\u3093<\/li>\n\n\n\n<li>T\u7d30\u80de\u7570\u5e38\u304c\u5f37\u3044\u60a3\u8005\u3055\u3093<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3001\u60a3\u8005\u3055\u3093\u3054\u3068\u306b\u75c5\u614b\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u4eca\u5f8c\u306f\u300c\u500b\u5225\u5316\u533b\u7642\u300d\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u306f\u4e00\u3064\u306e\u75c5\u6c17\u306e\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u304c\u3001\u5b9f\u969b\u306b\u306f\u75c5\u614b\u306e\u591a\u69d8\u6027\uff08heterogeneity\uff09\u304c\u975e\u5e38\u306b\u5927\u304d\u3044\u75be\u60a3\u3067\u3042\u308b\u3053\u3068\u304c\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306a\u80cc\u666f\u304b\u3089\u3001\u73fe\u5728\u306e\u7814\u7a76\u3067\u306f<strong>\u3059\u3079\u3066\u306e\u60a3\u8005\u3055\u3093\u306b\u540c\u3058\u85ac\u3092\u6295\u4e0e\u3059\u308b\u6642\u4ee3\u304b\u3089\u3001\u75c5\u614b\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u6642\u4ee3<\/strong>\u3078\u3068\u79fb\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u306b\u306f\u3001\u3069\u306e\u514d\u75ab\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b<strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong>\u306e\u958b\u767a\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u306f\u3001IFN\u30b7\u30b0\u30cd\u30c1\u30e3\u30fc\u3084BAFF\u95a2\u9023\u5206\u5b50\u3001\u81ea\u5df1\u6297\u4f53\u3001\u553e\u6db2\u817a\u7d44\u7e54\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306a\u3069\u3092\u5229\u7528\u3057\u3066\u60a3\u8005\u3055\u3093\u3092\u5c64\u5225\u5316\u3057\u3001\u305d\u308c\u305e\u308c\u306b\u6700\u9069\u306a\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b**Precision Medicine\uff08\u500b\u5225\u5316\u533b\u7642\uff09**\u306e\u5b9f\u73fe\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5f8c\u306f\u300c\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4\u300d\u3068\u3044\u3046\u4e00\u3064\u306e\u8a3a\u65ad\u540d\u3060\u3051\u3067\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u300c\u3069\u306e\u514d\u75ab\u7d4c\u8def\u304c\u305d\u306e\u60a3\u8005\u3055\u3093\u3067\u512a\u4f4d\u306b\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u300d\u3092\u8a55\u4fa1\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u3066\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u6642\u4ee3\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u611f\u60f3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3042\u3089\u305f\u3081\u3066\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u304c\u300c\u305f\u3060\u306e\u76ee\u3084\u53e3\u304c\u4e7e\u71e5\u3059\u308b\u75c5\u6c17\u300d\u3067\u306f\u306a\u304f\u8907\u96d1\u306a\u514d\u75ab\u7570\u5e38\u3092\u57fa\u790e\u3068\u3059\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308b\u3053\u3068\u304c\u4f1d\u308f\u3063\u3066\u304f\u308b\u5185\u5bb9\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u307e\u305f\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u65e2\u5b58\u306e\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306b\u5bfe\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u306e\u4e00\u90e8\u304c\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u306b\u5bfe\u3057\u3066\u3082\u6709\u52b9\u306a\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u8208\u5473\u6df1\u3044\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u81ea\u4f53\u304c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\u306b\u5408\u4f75\u3057\u3084\u3059\u3044\u75be\u60a3\u3067\u3042\u308a\u3001\u305d\u308c\u3089\u306e\u60a3\u8005\u3055\u3093\u3078\u306e\u6cbb\u7642\u85ac\u9078\u629e\u306e\u969b\u306b\u3082\u53c2\u8003\u306b\u306a\u308b\u5831\u544a\u3060\u3068\u611f\u3058\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u8fd1\u3044\u5c06\u6765\u306b\u3001\u3044\u305a\u308c\u304b\u306e\u85ac\u304c\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u81ea\u4f53\u3078\u306e\u6cbb\u7642\u306b\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p 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