{"id":77,"date":"2026-09-01T15:39:43","date_gmt":"2026-09-01T06:39:43","guid":{"rendered":"https:\/\/doicl.net\/blog\/?p=77"},"modified":"2026-09-04T21:45:46","modified_gmt":"2026-09-04T12:45:46","slug":"post-77","status":"publish","type":"post","link":"https:\/\/doicl.net\/blog\/post-77\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u85ac\u306f\u6e1b\u3089\u305b\u308b\uff1f\u5bdb\u89e3\u5f8c\u306e\u6e1b\u85ac\u30fb\u4e2d\u6b62\u306b\u3064\u3044\u3066|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af\uff08\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642\u3067\u306f\u3001\u5916\u6765\u6bce\u306b\u75c5\u6c17\u306e\u6d3b\u52d5\u6027\u3092\u8a55\u4fa1\u3057\u3001\u6d3b\u52d5\u6027\u304c\u6b8b\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308c\u3070\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306a\u3069\u306e\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3092\u5897\u91cf\u3057\u3001\u305d\u308c\u3067\u3082\u6cbb\u7642\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3067\u3042\u308c\u3070\u751f\u7269\u5b66\u7684\u88fd\u5264\u3084JAK\u963b\u5bb3\u85ac\u306a\u3069\u3092\u8ffd\u52a0\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u60a3\u8005\u3055\u3093\u304b\u3089\u300c\u85ac\u3092\u6e1b\u3089\u3059\u3053\u3068\u306f\u3067\u304d\u308b\uff1f\u300d\u300c\u3044\u3064\u304b\u85ac\u3092\u3084\u3081\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u3059\u304b\uff1f\u300d\u306a\u3069\u6e1b\u85ac\u306b\u95a2\u3059\u308b\u8cea\u554f\u3092\u3088\u304f\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3069\u306e\u3088\u3046\u306a\u60a3\u8005\u3055\u3093\u3067\u85ac\u3092\u6e1b\u3089\u305b\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u3060\u307e\u3060\u60a9\u307e\u3057\u3044\u3068\u3053\u308d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3053\u3067\u4eca\u65e5\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6e1b\u85ac\u306b\u95a2\u3059\u308b\u6587\u732e\u3092\u3054\u7d39\u4ecb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tapering of disease-modifying antirheumatic drugs: an overview for daily practice. Lancet Rheumatol. 2021 Sep;3(9):e659-e670.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306fAI\u8981\u7d04\u3092\u4e2d\u5fc3\u306b\u8ffd\u8a18\u30fb\u4fee\u6b63\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u85ac\u306f\u6e1b\u3089\u305b\u308b\uff1f<\/h1>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u305a\u3001\u300c\u6e1b\u85ac\u300d\u3068\u300c\u4e2d\u6b62\u300d\u306f\u540c\u3058\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u85ac\u3092\u6e1b\u3089\u3059\u65b9\u6cd5\u306b\u306f\u3001\u5927\u304d\u304f\u5206\u3051\u3066\u6b21\u306e\u3088\u3046\u306a\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6e1b\u85ac\u306e\u65b9\u6cd5<\/th><th>\u5177\u4f53\u4f8b<\/th><\/tr><\/thead><tbody><tr><td>\u2460 \u4f75\u7528\u3057\u3066\u3044\u308b\u85ac\u306e1\u5264\u3092\u4e2d\u6b62\u3059\u308b<\/td><td>MTX\uff0b\u751f\u7269\u5b66\u7684\u88fd\u5264\u304b\u30891\u5264\u3092\u4e2d\u6b62<\/td><\/tr><tr><td>\u2461 \u4f75\u7528\u85ac\u306e\u91cf\u3092\u6e1b\u3089\u3059<\/td><td>\u534a\u91cf\u306b\u3059\u308b\u3001\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3059<\/td><\/tr><tr><td>\u2462 \u5358\u5264\u6cbb\u7642\u3092\u5f90\u3005\u306b\u6e1b\u91cf\u3059\u308b<\/td><td>\u6700\u4f4e\u6709\u52b9\u91cf\u3092\u76ee\u6307\u3057\u3066\u5c11\u3057\u305a\u3064\u6e1b\u91cf<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u6bb5\u968e\u7684\u306b\u85ac\u3092\u6e1b\u3089\u3057\u3066\u3044\u304d\u3001\u6700\u7d42\u7684\u306b\u3059\u3079\u3066\u306e\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3092\u4e2d\u6b62\u3057\u305f\u72b6\u614b\u3067\u5bdb\u89e3\u304c\u7d9a\u3051\u3070\u3001**drug-free remission\uff08\u85ac\u3092\u4f7f\u308f\u306a\u3044\u5bdb\u89e3\uff09**\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u300c\u85ac\u3092\u6e1b\u3089\u305b\u308b\u3053\u3068\u300d\u3068\u300c\u85ac\u3092\u5b8c\u5168\u306b\u3084\u3081\u3089\u308c\u308b\u3053\u3068\u300d\u306f\u5225<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2460 \u751f\u7269\u5b66\u7684\u88fd\u5264\u306f\u6e1b\u3089\u305b\u308b\uff1f<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u4f7f\u7528\u3057\u3066\u5bdb\u89e3\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059<\/li>\n\n\n\n<li>\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3059<\/li>\n\n\n\n<li>\u6700\u7d42\u7684\u306b\u4e2d\u6b62\u3059\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u65b9\u6cd5\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001<strong>\u5b8c\u5168\u306b\u4e2d\u6b62\u3059\u308b\u3068\u518d\u71c3\u304c\u5897\u3048\u308b<\/strong>\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u307e\u3068\u3081\u3089\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u4e2d\u6b62\u3057\u305f\u5834\u5408\u3001\u7d99\u7d9a\u3057\u305f\u5834\u5408\u3068\u6bd4\u3079\u3066<strong>\u518d\u71c3\u304c\u7d0430\u301c33\uff05\u591a\u304f\u306a\u3063\u305f<\/strong>\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u3001\u6700\u5927\u306766\uff05\u304c\u5bdb\u89e3\u307e\u305f\u306f\u4f4e\u75be\u60a3\u6d3b\u52d5\u6027\u3092\u5931\u3063\u305f\u7814\u7a76\u3082\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u3044\u304d\u306a\u308a\u4e2d\u6b62\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u307e\u305a\u6e1b\u91cf\u3057\u305f\u308a\u3001\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3057\u305f\u308a\u3059\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u65b9\u6cd5\u304c\u3088\u304f\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f8b\u3048\u3070\u3001TNF\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30a2\u30c0\u30ea\u30e0\u30de\u30d6\u3084\u30a8\u30bf\u30cd\u30eb\u30bb\u30d7\u30c8\u3092\u6e1b\u91cf\u3057\u305fOPTTIRA\u8a66\u9a13\u3067\u306f\u300166\uff05\u307e\u3067\u5927\u304d\u304f\u6e1b\u91cf\u3057\u305f\u7fa4\u3067\u306f\u300133\uff05\u6e1b\u91cf\u7fa4\u3088\u308a\u518d\u71c3\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u6e1b\u85ac\u3059\u308b\u5834\u5408\u3067\u3082\u3001\u6e1b\u91cf\u5e45\u304c\u5927\u304d\u3044\u307b\u3069\u518d\u71c3\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305fDRESS\u8a66\u9a13\u3067\u306f\u3001TNF\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u9593\u9694\u3092\u75be\u60a3\u6d3b\u52d5\u6027\u306b\u5fdc\u3058\u3066\u5f90\u3005\u306b\u5ef6\u3070\u3057\u305f\u7fa4\u3068\u901a\u5e38\u91cf\u3092\u7d99\u7d9a\u3057\u305f\u7fa4\u30923\u5e74\u9593\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u300112\u9031\u9593\u4ee5\u4e0a\u6301\u7d9a\u3059\u308b\u300c\u5927\u304d\u306a\u518d\u71c3\uff08major flare\uff09\u300d\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6cbb\u7642<\/th><th>Major flare<\/th><\/tr><\/thead><tbody><tr><td>\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u9577<\/td><td><strong>10\uff05<\/strong><\/td><\/tr><tr><td>\u901a\u5e38\u91cf\u3092\u7d99\u7d9a<\/td><td><strong>12\uff05<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3001\u5927\u304d\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u3092\u9078\u3073\u3001\u75c5\u6c17\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u306a\u304c\u3089\u884c\u3048\u3070\u3001<strong>\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3059\u65b9\u6cd5\u306f\u73fe\u5b9f\u7684\u306a\u9078\u629e\u80a2<\/strong>\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2461 \u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306a\u3069\u306e\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3082\u6e1b\u3089\u305b\u308b\uff1f<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff09\u306a\u3069\u306e\u5f93\u6765\u578b\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u306b\u3064\u3044\u3066\u3082\u6e1b\u85ac\u306e\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8868\u7684\u306a\u306e\u304c<strong>ARCTIC REWIND\u8a66\u9a13<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c11\u306a\u304f\u3068\u308212\u304b\u6708\u9593\u5b89\u5b9a\u3057\u3066\u5bdb\u89e3\u3057\u3066\u3044\u305f155\u4eba\u3092\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>csDMARD\u3092\u901a\u5e38\u91cf\u306e\u307e\u307e\u7d99\u7d9a\u3059\u308b\u7fa4<\/li>\n\n\n\n<li>\u534a\u91cf\u306b\u6e1b\u91cf\u3059\u308b\u7fa4<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u5206\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u5e74\u9593\u3067\u518d\u71c3\u3057\u305f\u60a3\u8005\u3055\u3093\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6cbb\u7642<\/th><th>1\u5e74\u9593\u306e\u518d\u71c3\u7387<\/th><\/tr><\/thead><tbody><tr><td>\u901a\u5e38\u91cf\u3092\u7d99\u7d9a<\/td><td><strong>6\uff05<\/strong><\/td><\/tr><tr><td>\u534a\u91cf\u306b\u6e1b\u91cf<\/td><td><strong>25\uff05<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001\u534a\u91cf\u306b\u3059\u308b\u3068\u518d\u71c3\u306f\u5897\u3048\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u534a\u91cf\u306b\u3057\u3066\u3082\u7d0475\uff05\u306e\u60a3\u8005\u3055\u3093\u3067\u306f1\u5e74\u9593\u518d\u71c3\u3057\u306a\u304b\u3063\u305f<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u7d50\u679c\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u901a\u5e38\u91cf\u3092\u7d99\u7d9a\u3057\u305f\u7fa4\u3068\u6bd4\u8f03\u3059\u308b\u3068\u518d\u71c3\u30ea\u30b9\u30af\u306f\u660e\u3089\u304b\u306b\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u300c\u5bdb\u89e3\u3057\u3066\u3044\u308b\u304b\u3089\u5168\u54e1\u6e1b\u3089\u3059\u300d<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3082\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u300c\u518d\u71c3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u8ab0\u3082\u6e1b\u3089\u3055\u306a\u3044\u300d<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u6c17\u306e\u72b6\u614b\u3084\u3053\u308c\u307e\u3067\u306e\u7d4c\u904e\u3001\u526f\u4f5c\u7528\u306a\u3069\u3092\u898b\u306a\u304c\u3089\u60a3\u8005\u3055\u3093\u3054\u3068\u306b\u5224\u65ad\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2462 \u300c\u6e1b\u91cf\u300d\u3068\u300c\u5b8c\u5168\u4e2d\u6b62\u300d\u3067\u306f\u518d\u71c3\u7387\u304c\u9055\u3046<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e1b\u85ac\u306b\u3064\u3044\u3066\u975e\u5e38\u306b\u5206\u304b\u308a\u3084\u3059\u3044\u306e\u304c<strong>RETRO\u8a66\u9a13<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306a\u3069\u306e\u5f93\u6765\u578b\u6297\u30ea\u30a6\u30de\u30c1\u85ac\uff08csDMARD\uff09\u3084\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08bDMARD\uff09\u3092\u4f7f\u7528\u3057\u3066\u5bdb\u89e3\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3092\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f7f\u7528\u3057\u3066\u3044\u308bcsDMARD \/ bDMARD\u3092\u305d\u306e\u307e\u307e\u7d99\u7d9a<\/li>\n\n\n\n<li>\u4f7f\u7528\u3057\u3066\u3044\u308bcsDMARD \/ bDMARD\u309250\uff05\u306b\u6e1b\u91cf<\/li>\n\n\n\n<li>50\uff05\u306b\u6e1b\u91cf\u3057\u305f\u5f8c\u306b\u4e2d\u6b62<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306e3\u7fa4\u306b\u5206\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u203b\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u4f7f\u7528\u3057\u3066\u3044\u308bcsDMARD \/ bDMARD\u309250\uff05\u307e\u3067\u6e1b\u91cf\u3059\u308b\u6bd4\u8f03\u7684\u7a4d\u6975\u7684\u306a\u6e1b\u85ac\u65b9\u6cd5\u304c\u3068\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e2d\u9593\u89e3\u6790\u306b\u304a\u3051\u308b12\u304b\u6708\u5f8c\u306e\u518d\u71c3\u7387<\/strong>\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6cbb\u7642\u65b9\u91dd<\/th><th>1\u5e74\u9593\u306e\u518d\u71c3\u7387<\/th><\/tr><\/thead><tbody><tr><td>csDMARD \/ bDMARD\u3092\u7d99\u7d9a<\/td><td><strong>15.8\uff05<\/strong><\/td><\/tr><tr><td>csDMARD \/ bDMARD\u309250\uff05\u306b\u6e1b\u91cf<\/td><td><strong>38.9\uff05<\/strong><\/td><\/tr><tr><td>50\uff05\u6e1b\u91cf \u2192 \u4e2d\u6b62<\/td><td><strong>51.9\uff05<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u85ac\u3092\u6e1b\u3089\u3059\u3068\u518d\u71c3\u7387\u306f\u4e0a\u304c\u308a\u3001\u5b8c\u5168\u306b\u4e2d\u6b62\u3059\u308b\u3068\u3055\u3089\u306b\u4e0a\u304c\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u50be\u5411\u304c\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u300c\u85ac\u3092\u30bc\u30ed\u306b\u3059\u308b\u3053\u3068\u300d\u305d\u306e\u3082\u306e\u3092\u6cbb\u7642\u76ee\u6a19\u306b\u3059\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u6c17\u3092\u5b89\u5b9a\u3055\u305b\u306a\u304c\u3089\u3001\u305d\u306e\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u5fc5\u8981\u306a\u6cbb\u7642\u91cf\u3092\u63a2\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2463 \u85ac\u3092\u5b8c\u5168\u306b\u3084\u3081\u3089\u308c\u308b\u60a3\u8005\u3055\u3093\u3082\u4e00\u90e8\u306b\u306f\u3044\u308b<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u306f\u3001\u85ac\u3092\u5b8c\u5168\u306b\u3084\u3081\u308b\u3053\u3068\u306f\u4e0d\u53ef\u80fd\u306a\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BeSt\u7814\u7a76\u3067\u306f\u3001508\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u3064\u3044\u3066\u3001\u75c5\u6c17\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u306a\u304c\u3089\u85ac\u3092\u5f90\u3005\u306b\u6e1b\u3089\u3057\u3066\u3044\u3063\u305f\u3068\u3053\u308d\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>115\u4eba\uff0823\uff05\uff09\u304cdrug-free remission<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u5230\u9054\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u305d\u306e115\u4eba\u306e\u3046\u3061\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>53\u4eba\uff0846\uff05\uff09\u306f\u305d\u306e\u5f8c\u518d\u71c3<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u518d\u71c3\u3057\u305f\u60a3\u8005\u3055\u3093\u3067\u6700\u5f8c\u306b\u4e2d\u6b62\u3057\u305f\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3092\u518d\u958b\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>74\uff05\uff1a\u518d\u3073\u5bdb\u89e3<\/strong><\/li>\n\n\n\n<li><strong>21\uff05\uff1a\u4f4e\u75be\u60a3\u6d3b\u52d5\u6027<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u3067\u6539\u5584\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6e1b\u85ac\u5f8c\u306b\u518d\u71c3\u3057\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u3001\u6cbb\u7642\u304c\u53d6\u308a\u8fd4\u3057\u306e\u3064\u304b\u306a\u3044\u72b6\u614b\u306b\u306a\u308b\u308f\u3051\u3067\u306f\u306a\u3044<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u6c17\u304c\u518d\u3073\u52d5\u304d\u59cb\u3081\u305f\u5834\u5408\u306b\u306f\u3001\u901f\u3084\u304b\u306b\u85ac\u3092\u5143\u306e\u91cf\u306b\u623b\u3057\u305f\u308a\u3001\u518d\u958b\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u518d\u3073\u75c5\u6c17\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2464 \u3069\u3093\u306a\u60a3\u8005\u3055\u3093\u306a\u3089\u6e1b\u85ac\u3057\u3084\u3059\u3044\uff1f<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u6e1b\u91cf\u30fb\u4e2d\u6b62\u3057\u3066\u3082\u518d\u71c3\u3057\u306b\u304f\u3044\u60a3\u8005\u3055\u3093\u306e\u7279\u5fb4\u3068\u3057\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c5\u6c17\u306e\u6d3b\u52d5\u6027\u304c\u975e\u5e38\u306b\u4f4e\u3044<\/li>\n\n\n\n<li>\u65e9\u671f\u306e\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/li>\n\n\n\n<li>ACPA\uff08\u6297CCP\u6297\u4f53\uff09\u9670\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u6642\u70b9\u3067\u306f\u300c\u3053\u306e\u60a3\u8005\u3055\u3093\u306a\u3089\u5b89\u5168\u306b\u85ac\u3092\u4e2d\u6b62\u3067\u304d\u308b\u300d\u3068\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f55\u304b\u6708\u5bdb\u89e3\u304c\u7d9a\u3044\u305f\u3089\u6e1b\u3089\u3057\u3066\u3088\u3044\u306e\u304b<\/li>\n\n\n\n<li>\u3069\u306e\u7a0b\u5ea6\u306e\u901f\u5ea6\u3067\u6e1b\u3089\u3059\u306e\u304b<\/li>\n\n\n\n<li>\u3069\u3053\u307e\u3067\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3059\u306e\u304b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u70b9\u306b\u3064\u3044\u3066\u3082\u3001\u660e\u78ba\u306a\u7b54\u3048\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u2465 \u6e1b\u85ac\u3059\u308b\u3068\u304d\u306b\u5927\u5207\u306a\u306e\u306f\u300c\u305d\u306e\u5f8c\u306e\u30d5\u30a9\u30ed\u30fc\u300d<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u85ac\u3092\u6e1b\u3089\u3059\u3053\u3068\u4ee5\u4e0a\u306b\u5927\u5207\u306a\u306e\u304c\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6e1b\u3089\u3057\u305f\u3042\u3068\u306b\u75c5\u6c17\u306e\u72b6\u614b\u3092\u304d\u3061\u3093\u3068\u78ba\u8a8d\u3059\u308b\u3053\u3068<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306e\u8457\u8005\u3089\u306f\u3001\u5b9f\u969b\u306e\u8a3a\u7642\u3067\u306f\u6301\u7d9a\u7684\u306aDAS\u5bdb\u89e3\u3001\u3057\u3070\u3057\u3070<strong>6\u304b\u6708\u4ee5\u4e0a\u306e\u5bdb\u89e3<\/strong>\u3092\u78ba\u8a8d\u3057\u305f\u60a3\u8005\u3055\u3093\u3067\u6e1b\u85ac\u3092\u691c\u8a0e\u3057\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u95a2\u7bc0\u75c7\u72b6<\/li>\n\n\n\n<li>\u75be\u60a3\u6d3b\u52d5\u6027<\/li>\n\n\n\n<li>\u753b\u50cf\u6240\u898b<\/li>\n\n\n\n<li>\u85ac\u306e\u526f\u4f5c\u7528<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3092\u898b\u306a\u304c\u3089\u3001\u6e1b\u91cf\u30fb\u4e2d\u6b62\u30fb\u518d\u5897\u91cf\u3092\u5224\u65ad\u3059\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3057\u3066\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u518d\u71c3\u3057\u305f\u5834\u5408\u306b\u85ac\u3092\u518d\u958b\u3057\u305f\u308a\u5143\u306e\u91cf\u306b\u623b\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3092\u3001\u6e1b\u85ac\u306e\u300c\u5931\u6557\u300d\u3068\u8003\u3048\u308b\u5fc5\u8981\u306f\u306a\u3044<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u8003\u3048\u65b9\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u5b9f\u969b\u306e\u8a3a\u7642\u3067\u3082\u975e\u5e38\u306b\u5927\u5207\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u60a3\u8005\u3055\u3093\u304c\u6700\u3082\u5fc3\u914d\u3057\u3066\u3044\u308b\u306e\u306f\u300c\u518d\u71c3\u300d<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e1b\u85ac\u306b\u3064\u3044\u3066\u306e\u60a3\u8005\u3055\u3093\u306e\u610f\u8b58\u3092\u8abf\u3079\u305f\u7814\u7a76\u3067\u306f\u3001\u60a3\u8005\u3055\u3093\u304c\u7279\u306b\u5fc3\u914d\u3057\u3066\u3044\u305f\u306e\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u85ac\u3092\u6e1b\u3089\u3057\u3066\u75c5\u6c17\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u304b\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3053\u3068\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u60aa\u304f\u306a\u3063\u305f\u3068\u304d\u306b\u3059\u3050\u8a3a\u3066\u3082\u3089\u3048\u308b\u306e\u304b\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u3082\u91cd\u8981\u8996\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u6e1b\u85ac\u3092\u884c\u3046\u5834\u5408\u306b\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b9a\u671f\u7684\u306b\u75c5\u6c17\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u3001\u518d\u71c3\u3057\u305f\u5834\u5408\u306b\u306f\u901f\u3084\u304b\u306b\u6cbb\u7642\u3092\u623b\u305b\u308b\u3053\u3068<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u3055\u3093\u3078\u306e\u5341\u5206\u306a\u8aac\u660e\u3068\u3001\u60a3\u8005\u3055\u3093\u3068\u4e3b\u6cbb\u533b\u304c\u76f8\u8ac7\u3057\u306a\u304c\u3089\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u3081\u3066\u3044\u304f\u3053\u3068\u3082\u5927\u5207\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u4e00\u5ea6\u85ac\u3092\u59cb\u3081\u305f\u3089\u3001\u4e00\u751f\u540c\u3058\u91cf\u3092\u7d9a\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bdb\u89e3\u304c\u5341\u5206\u306b\u7d9a\u3044\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u85ac\u306e\u91cf\u3092\u6e1b\u3089\u3057\u305f\u308a\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u6295\u4e0e\u9593\u9694\u3092\u5ef6\u3070\u3057\u305f\u308a\u3067\u304d\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u7814\u7a76\u7d50\u679c\u304b\u3089\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6e1b\u85ac\u306b\u3064\u3044\u3066\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068<\/th><th>\u5185\u5bb9<\/th><\/tr><\/thead><tbody><tr><td>\u85ac\u306e\u6e1b\u91cf<\/td><td>\u53ef\u80fd\u306a\u60a3\u8005\u3055\u3093\u306f\u3044\u308b<\/td><\/tr><tr><td>\u6e1b\u91cf\u5f8c<\/td><td>\u518d\u71c3\u30ea\u30b9\u30af\u306f\u3042\u308b\u7a0b\u5ea6\u4e0a\u6607\u3059\u308b<\/td><\/tr><tr><td>\u5b8c\u5168\u4e2d\u6b62<\/td><td>\u6e1b\u91cf\u3088\u308a\u3055\u3089\u306b\u518d\u71c3\u3057\u3084\u3059\u3044<\/td><\/tr><tr><td>drug-free 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