{"id":82,"date":"2026-09-08T17:34:22","date_gmt":"2026-09-08T08:34:22","guid":{"rendered":"https:\/\/doicl.net\/blog\/?p=82"},"modified":"2026-09-08T17:34:24","modified_gmt":"2026-09-08T08:34:24","slug":"post-82","status":"publish","type":"post","link":"https:\/\/doicl.net\/blog\/post-82\/","title":{"rendered":"\u5065\u5eb7\u8a3a\u65ad\u3067\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u56e0\u5b50\uff08RF\uff09\u304c\u967d\u6027\u3002\u5c06\u6765\u30ea\u30a6\u30de\u30c1\u306b\u306a\u308b\uff1f|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af\uff08\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u3000\u5f53\u9662\u3092\u53d7\u8a3a\u3059\u308b\u60a3\u8005\u3055\u3093\u306e\u4e2d\u306b\u3001\u4e00\u5b9a\u6570\u300c\u5065\u8a3a\u3067RF\uff08\u30ea\u30a6\u30de\u30c1\u56e0\u5b50\uff09\u304c\u967d\u6027\u3068\u8a00\u308f\u308c\u305f\u306e\u3067\u53d7\u8a3a\u3057\u307e\u3057\u305f\u3002\u300d\u3068\u3044\u3046\u65b9\u304c\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u5065\u8a3a\u306e\u5224\u5b9a\u7d50\u679c\u3082\u3001\u300c\u8981\u7d4c\u904e\u89b3\u5bdf\u300d\u3001\u300c\u8981\u7cbe\u67fb\u300d\u3068\u5224\u5b9a\u7d50\u679c\u304c\u4e00\u5b9a\u3067\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u60a3\u8005\u3055\u3093\u304c\u56f0\u60d1\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u7d42\u7684\u306b\u300cRF\u304c\u967d\u6027\u3060\u3063\u305f\u3089\u75c5\u9662\u3092\u53d7\u8a3a\u3059\u308b\u3079\u304d\u3067\u3059\u304b\uff1f\u300d\u3068\u3044\u3046\u6839\u672c\u7684\u306a\u8cea\u554f\u3082\u3088\u304f\u304a\u805e\u304d\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u672c\u7684\u306b\u306f\u300c\u671d\u306e\u3053\u308f\u3070\u308a\u3084\u3001\u95a2\u7bc0\u306e\u75db\u307f\u306a\u3069\u304c\u3042\u308b\u5834\u5408\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c5\u306a\u3069\u4ed6\u306e\u81a0\u539f\u75c5\u3067\u3082RF\u304c\u967d\u6027\u306b\u306a\u308b\u3053\u3068\u306f\u3042\u308b\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u300d\u3068\u304a\u7b54\u3048\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305b\u3063\u304b\u304f\u306a\u306e\u3067\u4eca\u65e5\u306fRF\u967d\u6027\u306b\u95a2\u3059\u308b\u6587\u732e\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study. BMJ. 2012 Sep 6;345:e5244.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306fAI\u8981\u7d04\u3092\u4e2d\u5fc3\u306b\u8ffd\u8a18\u30fb\u4fee\u6b63\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u76ee\u7684<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u822c\u4eba\u53e3\u306b\u304a\u3044\u3066\u3001<strong>\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u56e0\u5b50\uff08RF\uff09\u304c\u9ad8\u5024\u3067\u3042\u308b\u3053\u3068\u304c\u3001\u5c06\u6765\u306e\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308b\u304b<\/strong>\u3092\u691c\u8a0e\u3057\u305f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5bfe\u8c61\u30fb\u65b9\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Copenhagen City Heart Study\u306b\u53c2\u52a0\u3057\u305f\u3001\u7814\u7a76\u958b\u59cb\u6642\u70b9\u3067RA\u306e\u306a\u3044<strong>9,712\u4eba<\/strong>\u3001\u5e74\u9f6220\u301c100\u6b73\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1981\u301c1983\u5e74\u306b\u63a1\u8840\u3057\u3001IgM-RF\u3092\u6e2c\u5b9a\u30022010\u5e74\u307e\u3067<strong>\u6700\u592728\u5e74\u9593<\/strong>\u8ffd\u8de1\u3057\u3066\u3044\u307e\u3059\u3002\u8ffd\u8de1\u4e2d\u306b<strong>183\u4eba\u304cRA\u3092\u767a\u75c7<\/strong>\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RF\u306f\u4ee5\u4e0b\u306e4\u7fa4\u306b\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>RF\u5024<\/th><th>\u4eba\u6570<\/th><\/tr><\/thead><tbody><tr><td>&lt;25 IU\/mL<\/td><td>9,294\u4eba<\/td><\/tr><tr><td>25\u201350 IU\/mL<\/td><td>176\u4eba<\/td><\/tr><tr><td>50.1\u2013100 IU\/mL<\/td><td>187\u4eba<\/td><\/tr><tr><td>&gt;100 IU\/mL<\/td><td>55\u4eba<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u306a\u7d50\u679c<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">RF\u5024\u304c\u9ad8\u3044\u307b\u3069\u3001\u5c06\u6765RA\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306f\u660e\u78ba\u306b\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RF &lt;25 IU\/mL\u3092\u57fa\u6e96\u3068\u3057\u305f\u591a\u5909\u91cf\u8abf\u6574\u5f8c\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>RF\u5024<\/th><th>RA\u767a\u75c7\u30cf\u30b6\u30fc\u30c9\u6bd4<\/th><\/tr><\/thead><tbody><tr><td>&lt;25<\/td><td>1.0<\/td><\/tr><tr><td>25\u201350<\/td><td><strong>3.6<\/strong><\/td><\/tr><tr><td>50.1\u2013100<\/td><td><strong>6.0<\/strong><\/td><\/tr><tr><td>&gt;100<\/td><td><strong>26<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001<strong>RF\u5024\u304c2\u500d\u306b\u306a\u308b\u3054\u3068\u306bRA\u767a\u75c7\u30ea\u30b9\u30af\u306f3.3\u500d<\/strong>\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">10\u5e74\u9593\u306e\u7d76\u5bfe\u30ea\u30b9\u30af<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u3082RA\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u306e\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>50\u301c69\u6b73\u306e\u5973\u6027\u3001\u55ab\u7159\u8005\u3001RF &gt;100 IU\/mL<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306e\u7fa4\u3067\u3001**10\u5e74\u9593\u306eRA\u767a\u75c7\u7387\u306f32\uff05**\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u9ad8\u30ea\u30b9\u30af\u7fa4\u3067\u306f\u7d043\u4eba\u306b1\u4eba\u304c10\u5e74\u4ee5\u5185\u306bRA\u3092\u767a\u75c7\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">RF\u9ad8\u5024\u304b\u3089RA\u767a\u75c7\u307e\u3067\u306e\u671f\u9593<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">RA\u8a3a\u65ad\u307e\u3067\u306e\u4e2d\u592e\u5024\u306f\u3001<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>RF\u5024<\/th><th>RA\u8a3a\u65ad\u307e\u3067\u306e\u4e2d\u592e\u5024<\/th><\/tr><\/thead><tbody><tr><td>&lt;25<\/td><td>15\u5e74<\/td><\/tr><tr><td>25\u201350<\/td><td>12\u5e74<\/td><\/tr><tr><td>50.1\u2013100<\/td><td>7\u5e74<\/td><\/tr><tr><td>&gt;100<\/td><td>7\u5e74<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RF\u306f<strong>\u81e8\u5e8a\u7684\u306a\u95a2\u7bc0\u708e\u304c\u51fa\u73fe\u3059\u308b\u304b\u306a\u308a\u524d\u304b\u3089\u9ad8\u5024\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b<\/strong>\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4ed6\u306e\u81ea\u5df1\u514d\u75ab\u6027\u30ea\u30a6\u30de\u30c1\u75be\u60a3\u3068\u306e\u95a2\u9023<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">RF\u304c2\u500d\u306b\u306a\u308b\u3054\u3068\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>RA\uff1a<strong>3.3\u500d<\/strong><\/li>\n\n\n\n<li>Sj\u00f6gren\u75c7\u5019\u7fa4\uff1a1.8\u500d<\/li>\n\n\n\n<li>SLE\uff1a2.5\u500d<\/li>\n\n\n\n<li>\u5168\u8eab\u6027\u5f37\u76ae\u75c7\uff1a3.1\u500d<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u50be\u5411\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001RA\u4ee5\u5916\u306e\u75be\u60a3\u306f\u767a\u75c7\u6570\u304c\u5c11\u306a\u304f\u3001<strong>\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3068\u306f\u8a00\u3048\u306a\u3044\u7d50\u679c<\/strong>\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">RA\u767a\u75c7\u6642\u306eRF\u967d\u6027\u7387\u306b\u3064\u3044\u3066<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8ad6\u6587\u3067\u306f\u3001RA\u60a3\u8005\u306eRF\u967d\u6027\u7387\u306b\u3064\u3044\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u75c7\u6642\uff1a\u7d0440\uff05<\/strong><\/li>\n\n\n\n<li>\u7d4c\u904e\u4e2d\u306b\u306f\u6700\u7d42\u7684\u306b\uff1a\u7d0480\uff05<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u305f\u3081\u3001\u65e9\u671fRA\u3067\u306fRF\u9670\u6027\u4f8b\u304c\u304b\u306a\u308a\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5e74\u9f62\u3068RF<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u822c\u306b\u300cRF\u306f\u52a0\u9f62\u3067\u4e0a\u6607\u3059\u308b\u300d\u3068\u8a00\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001<strong>20\u301c100\u6b73\u307e\u3067RF\u5024\u306f\u307b\u307c\u4e00\u5b9a<\/strong>\u3067\u3001\u660e\u3089\u304b\u306a\u5e74\u9f62\u4f9d\u5b58\u6027\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u306e\u5f37\u307f<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e00\u822c\u4eba\u53e3\u304b\u3089\u7121\u4f5c\u70ba\u62bd\u51fa\u3055\u308c\u305f\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8<\/li>\n\n\n\n<li>9,712\u4eba<\/li>\n\n\n\n<li>\u6700\u592728\u5e74\u9593\u306e\u9577\u671f\u8ffd\u8de1<\/li>\n\n\n\n<li>\u8ffd\u8de1\u7387100\uff05<\/li>\n\n\n\n<li>RF\u6e2c\u5b9a\u5024\u306f\u7814\u7a76\u671f\u9593\u4e2d\u3001\u60a3\u8005\u3084\u533b\u5e2b\u306b\u77e5\u3089\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u8a3a\u65ad\u884c\u52d5\u3078\u306e\u5f71\u97ff\u304c\u5c11\u306a\u3044<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u70b9\u304c\u5f37\u307f\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u9650\u754c<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u306a\u9650\u754c\u3068\u3057\u3066\u3001<\/p>\n\n\n\n<ul 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