\u3000\u8a3a\u7642\u306e\u969b\u306b\u3088\u304f\u805e\u304b\u308c\u308b\u8cea\u554f\u306b\u300c\u30ea\u30a6\u30de\u30c1\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3063\u3066\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3001\u3042\u308b\u3044\u306f\u300c\u30ea\u30a6\u30de\u30c1\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u3088\u3046\u306b\u6c17\u3092\u4ed8\u3051\u305f\u307b\u3046\u304c\u3044\u3044\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3068\u3044\u3046\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
\u98df\u751f\u6d3b\u306a\u3069\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u306e\u95a2\u9023\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u751f\u6d3b\u7fd2\u6163\u306f\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u304c\u3001\u307e\u305a\u4e00\u756a\u306b\u7981\u7159\u3092\u304a\u52e7\u3081\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
<\/p>\n\n\n\n
\u305b\u3063\u304b\u304f\u3067\u3059\u306e\u3067\u55ab\u7159\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u95a2\u3059\u308b\u6587\u732e\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n
\u00a0Smoking and Rheumatoid Arthritis. Int. J. Mol. Sci.<\/em> 2014<\/strong>, 15<\/em>, 22279-22295.<\/p>\n\n\n\n \u4ee5\u4e0b\u306fAI\u8981\u7d04\u3092\u4e2d\u5fc3\u306b\u4e00\u90e8\u8ffd\u8a18\u30fb\u4fee\u6b63\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n <\/p>\n\n\n\n \u300c\u30bf\u30d0\u30b3\u306f\u80ba\u3084\u5fc3\u81d3\u306b\u60aa\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b9f\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u306e\u767a\u75c7\u3084\u6cbb\u7642\u52b9\u679c\u306b\u3082\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n 2014\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u30ec\u30d3\u30e5\u30fc\u8ad6\u6587 Smoking and Rheumatoid Arthritis<\/em> \u3067\u306f\u3001\u55ab\u7159\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3064\u3044\u3066\u3001\u767a\u75c7\u30ea\u30b9\u30af\u3001\u514d\u75ab\u5b66\u7684\u306a\u4ed5\u7d44\u307f\u3001\u6cbb\u7642\u3078\u306e\u5f71\u97ff\u307e\u3067\u5e45\u5e83\u304f\u307e\u3068\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3053\u308c\u307e\u3067\u306e\u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u4ee3\u8868\u7684\u306a\u74b0\u5883\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u4e00\u3064<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u7d39\u4ecb\u3055\u308c\u3066\u3044\u308b\u30e1\u30bf\u89e3\u6790\u3067\u306f\u3001\u55ab\u7159\u8005\u306f\u975e\u55ab\u7159\u8005\u3068\u6bd4\u3079\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d042\u500d<\/strong>\u3067\u3057\u305f\u3002\u5973\u6027\u306b\u9650\u3063\u305f\u89e3\u6790\u3067\u3082\u3001\u55ab\u7159\u8005\u3067\u306f\u7d041.3\u500d<\/strong>\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3055\u3089\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u300c\u304b\u306a\u308a\u306e\u30d8\u30d3\u30fc\u30b9\u30e2\u30fc\u30ab\u30fc\u3067\u306a\u3051\u308c\u3070\u5927\u4e08\u592b\u300d\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u70b9\u3067\u3059\u3002\u5225\u306e\u30e1\u30bf\u89e3\u6790\u3067\u306f\u3001\u751f\u6daf\u55ab\u7159\u91cf\u304c10 pack-years\u672a\u6e80\u3068\u3044\u3046\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u55ab\u7159\u6b74\u3067\u3082\u3001RA\u767a\u75c7\u3068\u306e\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305f<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u300cpack-years\uff08\u30d1\u30c3\u30af\u30a4\u30e4\u30fc\uff09\u300d\u3068\u306f\u7d2f\u7a4d\u55ab\u7159\u91cf\u306e\u76ee\u5b89\u3067\u3001<\/p>\n\n\n\n 1\u65e520\u672c\u309210\u5e74\u9593\uff1d10 pack-years<\/strong><\/p>\n\n\n\n \u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u3068\u3059\u3079\u3066\u306e\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u304c\u540c\u3058\u3088\u3046\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n \u7279\u306b\u95a2\u9023\u304c\u5f37\u3044\u306e\u304c\u3001RF\uff08\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u56e0\u5b50\uff09\u3084\u6297CCP\u6297\u4f53\u306a\u3069\u304c\u967d\u6027\u306b\u306a\u308b\u30bf\u30a4\u30d7\u306e\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u306b\u3088\u3063\u3066\u4f53\u5185\u3067\u86cb\u767d\u306e\u300c\u30b7\u30c8\u30eb\u30ea\u30f3\u5316\u300d\u304c\u8d77\u3053\u308a\u3001\u305d\u308c\u306b\u5bfe\u3057\u3066ACPA\uff08\u6297\u30b7\u30c8\u30eb\u30ea\u30f3\u5316\u86cb\u767d\u6297\u4f53\uff1a\u6297CCP\u6297\u4f53\u306a\u3069\uff09\u304c\u4f5c\u3089\u308c\u308b\u3053\u3068\u304c\u3001RA\u767a\u75c7\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3055\u3089\u306b\u3001HLA-DRB1 shared epitope\uff08SE\uff09\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u7684\u7d20\u56e0\u3092\u6301\u3064\u4eba\u3067\u306f\u3001\u55ab\u7159\u306b\u3088\u308b\u8840\u6e05\u967d\u6027RA\u306e\u30ea\u30b9\u30af\u304c\u3088\u308a\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3064\u307e\u308a\u3001<\/p>\n\n\n\n \u907a\u4f1d\u7684\u306a\u306a\u308a\u3084\u3059\u3055 \u00d7 \u55ab\u7159\u3068\u3044\u3046\u74b0\u5883\u56e0\u5b50<\/strong><\/p>\n\n\n\n \u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u767a\u75c7\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u306e\u5f71\u97ff\u306f\u4e00\u3064\u306e\u4ed5\u7d44\u307f\u3060\u3051\u3067\u306f\u8aac\u660e\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n \u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u55ab\u7159\u306b\u3088\u3063\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3084\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u5897\u52a0\u3057\u3001\u81ea\u5df1\u6297\u4f53\u306e\u7523\u751f\u3084DNA\u30e1\u30c1\u30eb\u5316\u306a\u3069\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u306b\u3082\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u6574\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u5b9f\u969b\u3001\u55ab\u7159\u8005\u3067\u306fCRP\u3060\u3051\u3067\u306a\u304f\u3001TNF-\u03b1\u3001IL-1\u3001IL-6\u3001IL-8\u306a\u3069\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3082\u6df1\u304f\u95a2\u4fc2\u3059\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u307e\u305f\u3001RA\u60a3\u8005\u306e\u6ed1\u819c\u7d30\u80de\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3067\u306f\u3001\u30bf\u30d0\u30b3\u7159\u7531\u6765\u6210\u5206\u306b\u3088\u3063\u3066IL-1\u3001IL-6\u3001IL-8\u306a\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u304c\u5897\u3048\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u306e\u5f71\u97ff\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3092\u300c\u767a\u75c7\u3057\u3084\u3059\u304f\u3059\u308b\u300d\u3060\u3051\u3067\u306f\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u7279\u306b\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001TNF\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u304c\u55ab\u7159\u8005\u3067\u306f\u4f4e\u304f\u306a\u308b\u53ef\u80fd\u6027<\/strong>\u306b\u3064\u3044\u3066\u8907\u6570\u306e\u7814\u7a76\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n British Society for Rheumatology Biologics Register\u306e\u7814\u7a76\u3067\u306f\u3001\u55ab\u7159\u3057\u3066\u3044\u308bRA\u60a3\u8005\u3067\u306f\u3001TNF\u963b\u5bb3\u85ac\u30a4\u30f3\u30d5\u30ea\u30ad\u30b7\u30de\u30d6\u3078\u306e\u81e8\u5e8a\u53cd\u5fdc\u304c\u4f4e\u304f\u3001<\/p>\n\n\n\n OR 0.77\uff0895%CI 0.60\u20130.99\uff09<\/strong><\/p>\n\n\n\n \u3067\u3057\u305f\u3002<\/p>\n\n\n\n \u3055\u3089\u306b\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u55ab\u7159\u8005\u304cTNF\u963b\u5bb3\u85ac\u3067EULAR moderate response\u3092\u5f97\u3089\u308c\u308b\u30aa\u30c3\u30ba\u304c\u3001<\/p>\n\n\n\n OR 0.20\uff0895%CI 0.05\u20130.83\uff09<\/strong><\/p>\n\n\n\n \u3068\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n OR\u304c1\u3088\u308a\u5c0f\u3055\u3044\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u975e\u55ab\u7159\u8005\u3068\u6bd4\u8f03\u3057\u3066\u826f\u597d\u306a\u6cbb\u7642\u53cd\u5fdc\u3092\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f<\/strong>\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002<\/p>\n\n\n\n \u306a\u305c\u55ab\u7159\u8005\u3067\u85ac\u304c\u52b9\u304d\u306b\u304f\u304f\u306a\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001TNF-\u03b1\u306a\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5897\u52a0\u3001\u85ac\u7269\u4ee3\u8b1d\u3078\u306e\u5f71\u97ff\u3001\u6297\u85ac\u7269\u6297\u4f53\u306a\u3069\u8907\u6570\u306e\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u307e\u305f\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u55ab\u7159\u8005\u3067\u306f\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u30fb\u30dd\u30ea\u30b0\u30eb\u30bf\u30e1\u30fc\u30c8\u6fc3\u5ea6\u304c\u4f4e\u304b\u3063\u305f<\/strong>\u3068\u3044\u3046\u7814\u7a76\u3082\u7d39\u4ecb\u3055\u308c\u3066\u304a\u308a\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u4f5c\u7528\u306b\u3082\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u305f\u3060\u3057\u3001\u3053\u306e2014\u5e74\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u6cbb\u7642\u52b9\u679c\u4f4e\u4e0b\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u6700\u3082\u5145\u5b9f\u3057\u3066\u3044\u308b\u306e\u306fTNF\u963b\u5bb3\u85ac<\/strong>\u3067\u3059\u3002\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u306e\u5f8c\u3055\u3089\u306b\u7814\u7a76\u304c\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u3001\u80ba\u75c5\u5909\u3001\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u7d50\u7bc0\u3001\u8840\u7ba1\u708e\u306a\u3069\u300c\u95a2\u7bc0\u5916\u75c5\u5909\u300d\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u7814\u7a76\u3067\u306f\u3001RA\u8a3a\u65ad\u6642\u306e\u55ab\u7159\u306f\u91cd\u75c7\u306e\u95a2\u7bc0\u5916\u75c5\u5909\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308a\u3001<\/p>\n\n\n\n RR 2.94<\/strong><\/p>\n\n\n\n \u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n \u4e00\u65b9\u3001\u55ab\u7159\u304cX\u7dda\u4e0a\u306e\u95a2\u7bc0\u7834\u58ca\u305d\u306e\u3082\u306e\u3092\u72ec\u7acb\u3057\u3066\u9032\u884c\u3055\u305b\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u7814\u7a76\u7d50\u679c\u304c\u4e00\u81f4\u3057\u3066\u304a\u3089\u305a\u3001ACPA\u3092\u4ecb\u3057\u305f\u5f71\u97ff\u3067\u3042\u308b\u53ef\u80fd\u6027\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3064\u3044\u3066\u3001\u73fe\u5728\u307e\u3067\u306b\u7279\u306b\u91cd\u8981\u306a\u306e\u306f\u6b21\u306e\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n \u55ab\u7159\u306f\u3001\u5358\u306b\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3092\u767a\u75c7\u3057\u3084\u3059\u304f\u3059\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u767a\u75c7\u5f8c\u306e\u708e\u75c7\u3084\u6cbb\u7642\u53cd\u5fdc\u306b\u3082\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u56e0\u5b50<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n \u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306e\u8457\u8005\u3089\u3082\u3001\u55ab\u7159\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u708e\u75c7\u3001\u81ea\u5df1\u6297\u4f53\u7523\u751f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u304cRA\u306e\u81ea\u5df1\u514d\u75ab\u306b\u95a2\u308f\u308a\u3001\u3055\u3089\u306b\u6297TNF\u6cbb\u7642\u3078\u306e\u53cd\u5fdc\u306b\u3082\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3000\u611f\u60f3<\/p>\n\n\n\n \u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e0a\u3052\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u767a\u75c7\u5f8c\u306e\u6cbb\u7642\u52b9\u679c\u306b\u3082\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u4eca\u56de\u306e\u30ec\u30d3\u30e5\u30fc\u5185\u3067\u306f\u3001\u55ab\u7159\u8005\u3067\u306fTNF\u963b\u5bb3\u85ac\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u53cd\u5fdc\u304c\u4f4e\u3044\u3053\u3068\u304c\u8907\u6570\u306e\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u307e\u305f\u4ed6\u306e\u6587\u732e\u3067\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u524d\u306b\u4f7f\u7528\u3059\u308b\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u6709\u52b9\u6027\u3082\u4e0b\u3052\u308b\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(Mod Rheumatol. 2023 Dec 22;34(1):68-78.)<\/p>\n\n\n\n \u55ab\u7159\u3092\u3057\u3066\u3044\u308b\u3068\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u3067\u5341\u5206\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u305a\u3001\u9ad8\u984d\u306a\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u4f7f\u7528\u304c\u5fc5\u8981\u306b\u306a\u308b\u3002\u305d\u3057\u3066\u5c0e\u5165\u3057\u305fTNF\u963b\u5bb3\u85ac\u3082\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3002<\/p>\n\n\n\n \u3053\u306e\u3088\u3046\u306a\u6d41\u308c\u306b\u306a\u308b\u53ef\u80fd\u6027\u3082\u5341\u5206\u8003\u3048\u3089\u308c\u308b\u5831\u544a\u3067\u3059\u3002<\/p>\n\n\n\n \u3082\u3061\u308d\u3093\u3001\u55ab\u7159\u3057\u3066\u3044\u308b\u65b9\u3059\u3079\u3066\u3067\u6cbb\u7642\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u304f\u306a\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3057\u3001\u7981\u7159\u3059\u308c\u3070\u5fc5\u305a\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3092\u4e88\u9632\u3067\u304d\u308b\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n \u305d\u308c\u3067\u3082\u300c\u60a3\u8005\u3055\u3093\u81ea\u8eab\u3067\u5909\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u30ea\u30b9\u30af\u56e0\u5b50\u300d\u3068\u3057\u3066\u7981\u7159\u306e\u91cd\u8981\u6027\u304c\u6539\u3081\u3066\u5206\u304b\u308b\u5831\u544a\u3067\u3057\u305f\u3002<\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u3000\u8a3a\u7642\u306e\u969b\u306b\u3088\u304f\u805e\u304b\u308c\u308b\u8cea\u554f\u306b\u300c\u30ea\u30a6\u30de\u30c1\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3063\u3066\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3001\u3042\u308b\u3044\u306f\u300c\u30ea\u30a6\u30de\u30c1\u304c\u60aa\u304f\u306a\u3089\u306a\u3044\u3088\u3046\u306b\u6c17\u3092\u4ed8\u3051\u305f\u307b\u3046\u304c\u3044\u3044\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\uff1f…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-88","post","type-post","status-publish","format-standard","hentry","category-blog"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"\u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\uff1f\u767a\u75c7\u30ea\u30b9\u30af\u3068\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af(\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a) - \u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af \u30d6\u30ed\u30b0","description":"\u8a3a\u7642\u306e\u969b\u306b\u3088\u304f\u805e\u304b\u308c\u308b\u8cea\u554f\u306b\u300c\u30ea\u30a6\u30de\u30c1\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3063\u3066\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3001\u3042\u308b\u3044\u306f\u300c\u30ea\u30a6\u30de\u30c1\u304c\u60aa\u304f\u306a","canonical_url":"https:\/\/doicl.net\/blog\/post-88\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":null,"og:locale":"ja_JP","og:site_name":"\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af \u30d6\u30ed\u30b0 -","og:type":"article","og:title":"\u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\uff1f\u767a\u75c7\u30ea\u30b9\u30af\u3068\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af(\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a) - \u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af \u30d6\u30ed\u30b0","og:description":"\u8a3a\u7642\u306e\u969b\u306b\u3088\u304f\u805e\u304b\u308c\u308b\u8cea\u554f\u306b\u300c\u30ea\u30a6\u30de\u30c1\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3063\u3066\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3001\u3042\u308b\u3044\u306f\u300c\u30ea\u30a6\u30de\u30c1\u304c\u60aa\u304f\u306a","og:url":"https:\/\/doicl.net\/blog\/post-88\/","article:published_time":"2026-09-22T00:21:54+00:00","article:modified_time":"2026-09-22T00:21:55+00:00","twitter:card":"summary_large_image","twitter:title":"\u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\uff1f\u767a\u75c7\u30ea\u30b9\u30af\u3068\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af(\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a) - \u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af \u30d6\u30ed\u30b0","twitter:description":"\u8a3a\u7642\u306e\u969b\u306b\u3088\u304f\u805e\u304b\u308c\u308b\u8cea\u554f\u306b\u300c\u30ea\u30a6\u30de\u30c1\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3063\u3066\u3042\u308a\u307e\u3059\u304b\uff1f\u300d\u3001\u3042\u308b\u3044\u306f\u300c\u30ea\u30a6\u30de\u30c1\u304c\u60aa\u304f\u306a"},"aioseo_meta_data":{"post_id":"88","title":null,"description":null,"keywords":null,"keyphrases":{"focus":{"keyphrase":"","score":0,"analysis":{"keyphraseInTitle":{"score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_custom_url":null,"og_image_custom_fields":null,"og_image_url":null,"og_image_width":null,"og_image_height":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_image_url":null,"twitter_title":null,"twitter_description":null,"schema_type":"default","schema_type_options":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"BlogPosting","isEnabled":true},"graphs":[]},"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":null,"frequency":"default","local_seo":null,"limit_modified_date":false,"ai":{"faqs":[],"keyPoints":[],"schemas":[],"titles":[],"descriptions":[],"socialPosts":{"email":{"subject":"","preview":"","content":""},"linkedin":[],"twitter":[],"facebook":[],"instagram":[]}},"breadcrumb_settings":null,"seo_analyzer_scan_date":null,"created":"2026-09-22 00:21:55","updated":"2026-09-23 08:03:56","focus_keyword":null,"additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"\u55ab\u7159\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u3069\u3046\u5f71\u97ff\u3059\u308b\uff1f\u767a\u75c7\u30ea\u30b9\u30af\u3068\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066<\/h2>\n\n\n\n
\u55ab\u7159\u3059\u308b\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u306a\u308a\u3084\u3059\u3044\uff1f<\/h3>\n\n\n\n
\u7279\u306b\u300c\u6297CCP\u6297\u4f53\u967d\u6027\u300d\u306e\u30ea\u30a6\u30de\u30c1\u3068\u306e\u95a2\u4fc2\u304c\u5f37\u3044<\/h3>\n\n\n\n
\u306a\u305c\u30bf\u30d0\u30b3\u304c\u514d\u75ab\u306b\u5f71\u97ff\u3059\u308b\u306e\u304b<\/h3>\n\n\n\n
\u767a\u75c7\u3057\u305f\u5f8c\u306b\u3082\u5f71\u97ff\u3059\u308b\uff1f\u2015\u6cbb\u7642\u52b9\u679c\u3068\u306e\u95a2\u4fc2<\/h3>\n\n\n\n
\u95a2\u7bc0\u4ee5\u5916\u306e\u75c7\u72b6\u3068\u3082\u95a2\u4fc2\u3059\u308b\u53ef\u80fd\u6027<\/h3>\n\n\n\n
\u307e\u3068\u3081<\/h2>\n\n\n\n
\u55ab\u7159\u306e\u5f71\u97ff<\/th> \u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5185\u5bb9<\/th><\/tr><\/thead> RA\u767a\u75c7<\/td> \u55ab\u7159\u8005\u3067\u306f\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7d042\u500d<\/strong>\u3068\u306e\u5831\u544a<\/td><\/tr> \u5c11\u91cf\u306e\u55ab\u7159<\/td> 10 pack-years\u672a\u6e80<\/strong>\u3067\u3082\u767a\u75c7\u3068\u306e\u95a2\u9023\u3042\u308a<\/td><\/tr> RA\u306e\u30bf\u30a4\u30d7<\/td> \u7279\u306bRF\u30fb\u6297CCP\u6297\u4f53\u967d\u6027RA<\/strong>\u3068\u306e\u95a2\u9023\u304c\u5f37\u3044<\/td><\/tr> \u907a\u4f1d\u3068\u306e\u95a2\u4fc2<\/td> HLA-DRB1 SE \u00d7 \u55ab\u7159<\/strong>\u306e\u76f8\u4e92\u4f5c\u7528<\/td><\/tr> TNF\u963b\u5bb3\u85ac<\/td> \u55ab\u7159\u8005\u3067\u306f\u6cbb\u7642\u53cd\u5fdc\u304c\u4f4e\u3044\u3068\u306e\u8907\u6570\u306e\u5831\u544a<\/td><\/tr> \u95a2\u7bc0\u5916\u75c5\u5909<\/td> \u91cd\u75c7\u95a2\u7bc0\u5916\u75c5\u5909\u3068\u306e\u95a2\u9023\u3092\u793a\u3059\u7814\u7a76\u3042\u308a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n