{"id":93,"date":"2026-10-06T11:17:13","date_gmt":"2026-10-06T02:17:13","guid":{"rendered":"https:\/\/doicl.net\/blog\/?p=93"},"modified":"2026-10-13T15:27:56","modified_gmt":"2026-10-13T06:27:56","slug":"post-93","status":"publish","type":"post","link":"https:\/\/doicl.net\/blog\/post-93\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306f\u95a2\u7bc0\u3060\u3051\u306e\u75c5\u6c17\u3067\u306f\u306a\u3044\uff1f\u80ba\u30fb\u76ee\u30fb\u76ae\u819a\u306a\u3069\u306b\u8d77\u3053\u308b\u300c\u95a2\u7bc0\u5916\u75c5\u5909\u300d|\u5fa1\u6240\u5357\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u3069\u3044\u30af\u30ea\u30cb\u30c3\u30af\uff08\u4eac\u90fd\u5e02\u4e2d\u4eac\u533a\uff09"},"content":{"rendered":"\n<p 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class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306f\u95a2\u7bc0\u3060\u3051\u306b\u9650\u5c40\u3057\u305f\u75c5\u6c17\u3067\u306f\u306a\u304f\u3001\u514d\u75ab\u306e\u7570\u5e38\u3084\u5168\u8eab\u306e\u708e\u75c7\u3092\u80cc\u666f\u3068\u3057\u3066\u3001<strong>\u80ba\u3001\u76ee\u3001\u76ae\u819a\u3001\u8840\u7ba1\u3001\u8840\u6db2\u306a\u3069\u95a2\u7bc0\u4ee5\u5916\u306e\u81d3\u5668\u306b\u3082\u3055\u307e\u3056\u307e\u306a\u75c5\u5909\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u7bc0\u5916\u75c5\u5909\u3068\u306f\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u4f34\u3063\u3066\u95a2\u7bc0\u4ee5\u5916\u306b\u751f\u3058\u308b\u75c5\u5909\u3092\u3001\u4e00\u822c\u306b**\u95a2\u7bc0\u5916\u75c5\u5909\uff08extra-articular manifestations\uff1aEAMs\uff09**\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u95a2\u7bc0\u5916\u75c5\u5909\u306f\u6c7a\u3057\u3066\u73cd\u3057\u3044\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u904e\u53bb\u306e\u7814\u7a76\u3067\u306f<strong>\u7d0440\uff05\u306e\u60a3\u8005\u3055\u3093\u306b\u4f55\u3089\u304b\u306e\u95a2\u7bc0\u5916\u75c5\u5909\u304c\u307f\u3089\u308c\u308b<\/strong>\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u300c\u4f55\u3092\u95a2\u7bc0\u5916\u75c5\u5909\u306b\u542b\u3081\u308b\u304b\u300d\u306b\u3064\u3044\u3066\u7d71\u4e00\u3055\u308c\u305f\u53b3\u5bc6\u306a\u5b9a\u7fa9\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u7814\u7a76\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u983b\u5ea6\u306b\u306f\u304b\u306a\u308a\u5e45\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u5916\u75c5\u5909\u3068\u95a2\u9023\u3059\u308b\u56e0\u5b50\u3068\u3057\u3066\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u56e0\u5b50\uff08RF\uff09\u967d\u6027\u3001ANA\u967d\u6027\u3001\u95a2\u7bc0\u7834\u58ca\u3001\u55ab\u7159\u3001\u7537\u6027\u3001\u7279\u5b9a\u306eHLA\u907a\u4f1d\u5b50\u578b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306bRF\u967d\u6027\u306f\u3001\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u7d50\u7bc0\u3001\u8840\u7ba1\u708e\u3001Felty\u75c7\u5019\u7fa4\u3001\u6f3f\u819c\u708e\u306a\u3069\u306e\u95a2\u7bc0\u5916\u75c5\u5909\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u304b\u3089\u306f\u4e3b\u306a\u75c5\u5909\u3092\u81d3\u5668\u3054\u3068\u306b\u307f\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1\uff0e\u80ba\u306e\u75c5\u5909<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u95a2\u7bc0\u5916\u75c5\u5909\u306e\u306a\u304b\u3067\u3082\u3001\u81e8\u5e8a\u7684\u306b\u7279\u306b\u91cd\u8981\u306a\u306e\u304c<strong>\u80ba\u75c5\u5909<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80ba\u75c5\u5909\u5168\u4f53\u306b\u3064\u3044\u3066\u306f\u3001\u7814\u7a76\u306b\u3088\u3063\u3066**10\uff5e67\uff05**\u3068\u975e\u5e38\u306b\u5e45\u5e83\u3044\u983b\u5ea6\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u5185\u5bb9\u3082\u4e00\u3064\u3067\u306f\u306a\u304f\u3001<\/p>\n\n\n\n<ul 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class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u80f8\u819c\u708e<br>\u5fc3\u819c\u708e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u3001\u81d3\u5668\u3092\u5305\u3080\u300c\u819c\u300d\u306b\u708e\u75c7\u3092\u8d77\u3053\u3059\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u691c\u67fb\u3067\u80f8\u6c34\u3092\u8abf\u3079\u308b\u3068<strong>\u6700\u592770\uff05<\/strong>\u3001\u5fc3\u56a2\u6db2\u306b\u3064\u3044\u3066\u306f**30\uff5e50\uff05**\u306b\u8a8d\u3081\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u5b9f\u969b\u306b\u75c7\u72b6\u3092\u4f34\u3046\u3082\u306e\u306f\u305a\u3063\u3068\u5c11\u306a\u304f\u3001<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u75c7\u5019\u6027\u80f8\u819c\u708e\uff1a3\uff5e5\uff05<br>\u75c7\u5019\u6027\u5fc3\u819c\u708e\uff1a10\uff05\u672a\u6e80<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3064\u307e\u308a\u3001\u753b\u50cf\u691c\u67fb\u306a\u3069\u3067\u5c11\u91cf\u306e\u80f8\u6c34\u30fb\u5fc3\u56a2\u6db2\u304c\u307f\u3064\u304b\u308b\u3053\u3068\u3068\u3001\u81e8\u5e8a\u7684\u306b\u554f\u984c\u3068\u306a\u308b\u80f8\u819c\u708e\u30fb\u5fc3\u819c\u708e\u306f\u5206\u3051\u3066\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80f8\u819c\u3084\u5fc3\u819c\u306e\u5c40\u6240\u3067\u306fRF\u3084\u514d\u75ab\u8907\u5408\u4f53\u304c\u7523\u751f\u3055\u308c\u3001\u95a2\u7bc0\u6ed1\u819c\u708e\u3068\u5171\u901a\u3059\u308b\u708e\u75c7\u6a5f\u5e8f\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4\uff0e\u76ee\u306e\u75c5\u5909<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u773c\u75c5\u5909\u3082\u6bd4\u8f03\u7684\u3088\u304f\u307f\u3089\u308c\u3001**\u7d0418\uff05**\u306b\u4f55\u3089\u304b\u306e\u773c\u75c5\u5909\u304c\u8a8d\u3081\u3089\u308c\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8868\u7684\u306a\u3082\u306e\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e7e\u6027\u89d2\u7d50\u819c\u708e\uff08\u30c9\u30e9\u30a4\u30a2\u30a4\uff09<\/li>\n\n\n\n<li>\u4e0a\u5f37\u819c\u708e<\/li>\n\n\n\n<li>\u5f37\u819c\u708e<\/li>\n\n\n\n<li>\u672b\u68a2\u6027\u6f70\u760d\u6027\u89d2\u819c\u708e\uff08PUK\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3067\u3059\u3002 biomedicines-11-01262<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u306a\u304b\u3067\u306f\u4e7e\u6027\u89d2\u7d50\u819c\u708e\u304c\u6700\u3082\u591a\u304f\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001<strong>\u5f37\u819c\u708e\u3084\u672b\u68a2\u6027\u6f70\u760d\u6027\u89d2\u819c\u708e<\/strong>\u306f\u983b\u5ea6\u3053\u305d\u9ad8\u304f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u708e\u75c7\u304c\u5f37\u3044\u5834\u5408\u306b\u306f\u773c\u7d44\u7e54\u306e\u969c\u5bb3\u306b\u3064\u306a\u304c\u308b\u91cd\u8981\u306a\u95a2\u7bc0\u5916\u75c5\u5909\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u514d\u75ab\u8907\u5408\u4f53\u3001\u88dc\u4f53\u3001MMP\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff09\u306a\u3069\u304c\u75c5\u614b\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5\uff0e\u8840\u6db2\u306e\u7570\u5e38<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u3001<\/p>\n\n\n\n<ul 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class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u7dcf\u8aac\u306f\u3001**\u300c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306f\u95a2\u7bc0\u3060\u3051\u3092\u898b\u308b\u75c5\u6c17\u3067\u306f\u306a\u3044\u300d**\u3068\u3044\u3046\u3053\u3068\u3092\u3001\u3055\u307e\u3056\u307e\u306a\u81d3\u5668\u306e\u75c5\u614b\u304b\u3089\u6574\u7406\u3057\u305f\u30ec\u30d3\u30e5\u30fc\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u611f\u60f3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u3082\u3061\u308d\u3093\u91cd\u8981\u306a\u306e\u306f\u95a2\u7bc0\u75c7\u72b6\u3067\u3059\u304c\u3001\u610f\u5916\u3068\u95a2\u7bc0\u4ee5\u5916\u306b\u3082\u75c7\u72b6\u304c\u3042\u308b\u65b9\u304c\u591a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p 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